At the recent Sydney.Net User Group TJ Gokcen was showing a bug that required him to launch a Silverlight Website in Chrome to reproduce.
The workaround to launch Chrome by changing default browser was quite cumbersome and I mentioned a great Visual Studio 2010 Extension that makes it easy to Start > Debug into a different browser at the click of a button. This is great for checking CSS etc in different browsers rather quickly.
To install you can either go to the following URL or Open up the VS2010 Extension Manager by clicking Tools > Extention Manager

Figure: Under tools Menu is the new VS2010 Extension Manager
Click Online Gallery and Search for “Browser switcher” then click on the World of VS Default Browser Switcher and install.

Figure: Searching for Extensions in VS2010 is ever so easy
Once installed it will require a restart of VS2010 and then you need to turn on the toolbar by Right Clicking a blank area of the toolbar and selecting Default Browser Switcher (it would be nice if it did this automatically on install) 
Figure: Adding the toolbar to VS2010
Now you have a toolbar that you can click the appropriate browser icon and F5 to Start Debugging which will launch the ASP.NET Website in that browser.
Note: Even though it shows other browsers such as Opera and Safari which I do not have installed, it is smart enough to now allow you to select these if not installed :)

Figure: New toolbar with browser icons